Environmental Regulation of Prions in Yeast
نویسندگان
چکیده
منابع مشابه
Environmental Regulation of Prions in Yeast
The term prion, proteinaceus infectious particle, was first used to describe the causative agent of a group of mammalian neurodegenerative diseases known as transmissible spongiform encephalopathies (TSEs) [1]. The mammalian prion protein (PrP) can exist in either a normal cellular conformation, PrP, or in multiple misfolded pathogenic conformations, collectively called PrP. PrP is considered i...
متن کاملPrions in yeast.
The concept of a prion as an infectious self-propagating protein isoform was initially proposed to explain certain mammalian diseases. It is now clear that yeast also has heritable elements transmitted via protein. Indeed, the "protein only" model of prion transmission was first proven using a yeast prion. Typically, known prions are ordered cross-β aggregates (amyloids). Recently, there has be...
متن کاملYeast and Fungal Prions.
Yeast and fungal prions are infectious proteins, most being self-propagating amyloids of normally soluble proteins. Their effects range from a very mild detriment to lethal, with specific effects dependent on the prion protein and the specific prion variant ("prion strain"). The prion amyloids of Sup35p, Ure2p, and Rnq1p are in-register, parallel, folded β-sheets, an architecture that naturally...
متن کاملSpermidine cures yeast of prions
Prions are self-perpetuating amyloid protein aggregates which underlie various neurodegenerative diseases in mammals. The molecular basis underlying their conversion from a normally soluble protein into the prion form remains largely unknown. Studies aimed at uncovering these mechanism(s) are therefore essential if we are to develop effective therapeutic strategies to counteract these disease-c...
متن کاملTranslation termination and yeast prions.
Protein biosynthesis is the final step in the transfer of genetic information in the cell. In turn, its last step is the release of a nascent polypeptide from the ribosome. Therefore, termination of translation may be considered (if we do not take into account protein post-translational modification and folding) as a final step of the transition from genotype to phenotype through the classic DN...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS Pathogens
سال: 2012
ISSN: 1553-7374
DOI: 10.1371/journal.ppat.1002973